Below are current clinical trials.23 studies in Alzheimer's disease
(open studies only).
Filter this list of studies by location, status and more.
This study consists of two parts, Part I and Part II. The purpose of Part I of the study is to assess the efficacy and safety of verubecestat (MK-8931) compared with placebo administered for 104 weeks in the treatment of amnestic mild cognitive impairment (aMCI) due to Alzheimer's Disease (AD), also known as prodromal AD. Participants will be randomized to receive placebo, or 12 mg or 40 mg verubecestat, once daily. The primary study hypothesis for Part I is that at least one verubecestat dose is superior to placebo with respect to the change from baseline in the Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) score at 104 weeks. Participants who complete Part I of the study may choose to participate in Part II, which is a long term double-blind extension to assess efficacy and safety of verubecestat administered for up to an additional 260 weeks. In Part II, all participants will receive either 12 mg or 40 mg verubecestat, once daily.
Jacksonville, Fla., Rochester, Minn.
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD. ADNI3 continues the previously funded ADNI-1, ADNI-GO, and ADNI-2 studies that have been combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD). The overall goal of the study is to continue to discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research.
Jacksonville, Fla., Rochester, Minn.
To further investigate biomarkers in CSF as possible predictors for mild cognitive impairment and dementia
Aug. 11, 2017
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- Adopt a healthy diet. Alzheimer's Association. http://www.alz.org/we_can_help_adopt_a_healthy_diet.asp. Accessed Oct. 7, 2015.