Below are current clinical trials.3 studies in Allergies
(open studies only).
Filter this list of studies by location, status and more.
The aim of this study is to examine the role of mast cell mediators in children with allergic disorders in a two part study. Part 1 of the study will prospectively obtain the values of mast cell mediators, including 2,3 dinor 11β-PGF2α, n-MH, and LTE4 in the urine of a healthy pediatric reference population. Part 2 of the study will prospectively evaluate the urine concentrations of mast cell mediators in a cohort of pediatric allergic disorder patients including asthma, allergic rhinoconjunctivitis, eczema, urticaria, systemic anaphylaxis, and mast cell disorders, as well as POTS (postural orthostatic tachycardia syndrome). Comparisons of these values in the disease cohort will be made utilizing the pediatric expected reference intervals established in Part 1. Further analysis will determine if one or several urine mast cell mediators are elevated in a particular allergic disorder.
This study is being done to test the effects of an aeroallergen on eosinophils and other immune cells from your blood. These cells are involved in various human diseases such as allergies, asthma, and chronic rhinosinusitis. This study will find out how aeroallergens can activate eosinophils and other cells to cause diseases, and will lead to better understanding of the mechanisms of allergies, asthma, and chronic rhinosinusitis and help to develop new treatments for patients.
Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies. We aim to create a registry and biorepository of tissue and fluid specimens for future studies.
Aug. 07, 2017
- Allergy overview. Asthma and Allergy Foundation of America. http://aafa.org/display.cfm?id=9. Accessed May 28, 2017.
- Allergic reactions. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/library/at-a-glance/allergic-reactions.aspx. Accessed May 28, 2017.
- Seidman MD, et al. Clinical practice guideline: Allergic rhinitis. Otolaryngology — Head and Neck Surgery. 2015;152:S1.
- Allergies. American College of Allergy, Asthma & Immunology. http://acaai.org/allergies. Accessed May 28, 2017.
- Allergies and hay fever. American Academy of Otolaryngology — Head and Neck Surgery. http://www.entnet.org/content/allergies-and-hay-fever. Accessed May 28, 2017.
- Anaphylaxis. American Academy of Allergy, Asthma and Immunology. http://www.aaaai.org/conditions-and-treatments/allergies/anaphylaxis. Accessed May 28, 2017.
- Types of allergies. Asthma and Allergy Foundation of America. http://www.aafa.org/page/types-of-allergies.aspx. Accessed May 28, 2017.
- Who has allergies? American Academy of Allergy, Asthma and Immunology. http://acaai.org/allergies/who-has-allergies. Accessed May 28, 2017.
- What causes asthma? American Lung Association. http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/asthma/asthma-symptoms-causes-risk-factors/what-causes-asthma.html. Accessed May 28, 2017.
- Allergic rhinitis, sinusitis and rhinosinusitis. American Academy of Otolaryngology — Head and Neck Surgery. http://www.entnet.org/content/allergic-rhinitis-sinusitis-and-rhinosinusitis. Accessed May 28, 2017.
- Is rinsing your sinuses with neti pots safe? U.S. Food and Drug Administration. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm316375.htm. Accessed May 28, 2017.