Mayo Clinic researchers are working on ways to better diagnose and treat achalasia. Specific efforts include studies comparing the long-term effectiveness of various treatment options.

The Mayo Clinic Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program conducts laboratory and clinical research on disturbances to nerve function in the gastrointestinal tract.


See a list of publications by Mayo Clinic doctors on achalasia on PubMed, a service of the National Library of Medicine.

July 11, 2017
  1. Spechler SJ. Achalasia: Pathogenesis, clinical manifestations, and diagnosis. Accessed Feb. 3, 2017.
  2. Feldman M, et al. Esophageal neuromuscular function and motility disorders. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. Accessed Jan. 17, 2017.
  3. Sawas T, et al. The course of achalasia one to four decades after initial treatment. Alimentary Pharmacology and Therapeutics. 2017;45:553.
  4. Spechler SJ. Overview of the treatment of achalasia. Accessed Feb. 3, 2017.
  5. Krill JT, et al. Clinical management of achalasia: Current state of the art. Clinical and Experimental Gastroenterology. 2016;9:71.
  6. Bechara R, et al. POEM, the prototypical 'new NOTES' procedure and first successful NOTES procedure. Gastrointestinal Endoscopy Clinics of North America. 2016;26:237.
  7. Patti MG, et al. POEM vs laparoscopic Heller myotomy and fundoplication: Which is now the gold standard for treatment of achalasia? Journal of Gastrointestinal Surgery. 2017;21:207.
  8. Brown AY. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Jan. 24, 2017.