Diabetes

Clinical Trials

Below is a list of Diabetes clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

"Ffect of High Fat and High Glycemic Diets
The investigators will determine whether people with high muscle mitochondrial capacity produce higher amount of reactive oxygen species (ROS) on consuming high fat /high glycemic diet and thus exhibit elevated cellular oxidative damage.
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A Multicenter, Prospective, Observational Study With PriMatrix for the Treatment of Neuropathic Diabetic Foot Ulcers
To evaluate the effectiveness of PriMatrix in the treatment of DFUs in subjects without significantly compromised arterial circulation.
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A multiple-center, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of INGAP in patients with Type 1 diabetes mellitus.
We are conducting a research study to learn about the safety and efficacy of a drug for the treatment of diabetes. This study will help us to understand the effects from this drug and will help develop a new therapy for type 1 diabetes.
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A Pilot Study of Hemin Therapy for Gastroparesis (Diabetes Mellitus)
Heme oxygenase 1 (HO-1) is an enzyme which protects cells from physical, chemical, and biologic stress. In mice with diabetes and slow gastric emptying, hemin increases HO-1 activity and improves gastric emptying.
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An Evaluation of the Metabolic Effects of Exenatide, Rosiglitazone, and Exenatide plus Rosiglitazone in Subjects with Type 2 Diabetes Treated with Metformin
This study is being done to compare the effects of two drugs for the treatment of type 2 diabetes. This study will evaluate the effects of adding exenatide, rosiglitazone, or both to your current oral antidibetic medication (metformin).
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Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes
The overall goal of this proposal is to determine the effects of acute hyperglycemia and its modulation by Glucagon-like Peptide-1 (GLP-1) on myocardial perfusion in type 2 diabetes (DM). This study plan utilizes myocardial contrast echocardiography (MCE) to explore a) the effects of acute hyperglycemia on myocardial perfusion and coronary flow reserve in individuals with and without DM; and b) the effects of GLP-1
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Insulin Sensitizers on Mitochondrial ATP Production and Mitochondrial ATP Production and Mitochondrial Protein Synthesis on Insulin Resistant Type 2 Diabetes and Obesity
An association between insulin resistance and mitochondrial dysfunction has been observed in aging, T2D, and in offspring of patients with T2D. It remains to be determined whether pharmacological agents that enhance insulin sensitivity improve muscle mitochondrial function.
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Muscle Glucose Metabolism in Man
The overall purpose of this study is find out why too much fat in the blood stream may cause insulin resistance in muscles. Insulin is the hormone, produced normally by the body, which causes blood sugar to return to normal after eating.
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Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics
The Online Wound Electronic Medical Record (OWEMR) is a medical informatics tool that synthesizes data about complex wound problems from multiple sources and is innovative in its capability to performing these critical tasks: i) identification of the information needed to make treatment decisions at the point of care in real time ii) use intelligent search and report features to identify patients who require emergency
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Study to Assess Pharmacodynamics of RM-131 in Patients With Diabetic Gastroparesis
The purpose of this study is to evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) profile and the safety and tolerability of RM-131 in patients with diabetes mellitus and delayed gastric emptying.
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The Effect of an Investigational Drug on Blood Flow and Control of Blood Sugar in Subjects with Type 2 Diabetes Mellitus
Effect of an investigational drug, liraglutide vs placebo or a well known FDA approved anti-diabetic drug, glimepiride, in subjects with type 2 diabetes to see if liraglutide will improve blood flow and blood sugar control.
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