Desmoid Tumors

Clinical Trials

Below is a list of Desmoid Tumors clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Phase 2 Study of Sulindac (Clinoril) and Tamoxifen in Patients with Desmoid Tumors that are Recurrent or Not Amenable (Not Responding) to Standard Therapy
This study is being done to:
- Find the effects (good and bad) when combining sulindac and tamoxifen
- Find out if sulindac and tamoxifen are helpful in treating desmoid tumors
- Study tumor samples in a laboratory and find out if there is a way to tell if tumor cells will respond to treatment with sulindac and tamoxifen

Patients are being asked to take part in this study because they have a rare soft tissue tumor called a desmoid tumor (desmoid tumors are also called fibromatosis or aggressive fibromatosis). Surgery and/or radiation therapy are the standard treatment for these tumors, but sometimes, because of the location or size of the tumor, it is not possible to do surgery and/or radiation therapy. In other cases, these treatments are done and the tumor comes back (this is called recurrent tumor). Patients are being asked to take part in this study because their tumor cannot be treated with surgery and/or radiation, or because the tumor has come back.

Sulindac is a drug approved to treat inflammation in patients with arthritis. Several published reports suggest that sulindac may have anti-tumor activity in adults with desmoid tumor. Tamoxifen is an estrogen-blocking drug approved for the treatment of breast cancer. Researchers have reported that tamoxifen may have anti-tumor activity against desmoid tumors. Sulindac and tamoxifen have been investigated, separately and together, in recent clinical studies of adults and children with different types of tumor, including desmoid tumor. Pediatric researchers would like to find out if this combination of sulindac and tamoxifen, taken by mouth, can be taken by children and if this combination has anti-tumor activity against desmoid tumor in children whose tumor cannot be treated with surgery or radiation therapy or whose desmoid tumor has come back.
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