In addition to providing top-quality treatment, members of the Department of Radiation Oncology at Mayo Clinic in Minnesota are leaders in research advances on the effectiveness of cancer treatment.

Cancer research is conducted in coordination with the Mayo Clinic Cancer Center. The Mayo Clinic Cancer Center receives funding from the National Cancer Institute and is designated as a comprehensive cancer center — recognition for an institution's scientific excellence and multidisciplinary resources focused on cancer prevention, diagnosis and treatment.

Mayo Clinic in Minnesota participates in cooperative research groups, including Children's Oncology Group, Alliance for Clinical Trials in Oncology and NRG Oncology Group.