Renal Biopsy Laboratory

By Mayo Clinic Staff

The Renal Biopsy Laboratory in the Department of Laboratory Medicine and Pathology at the Mayo Clinic examines more than 6000 biopsies per year from nephrologists across the country.

The biopsy tissue and relevant clinical information are sent to the Mayo Clinic Renal Biopsy Laboratory through Mayo Medical Laboratories. To completely evaluate the biopsy, a portion is processed for light microscopy, a portion for electron microscopy, and a portion is frozen for evaluation by immunofluorescent histology. Each of these studies is important to fully examine the biopsy for specific types of injury such as antibody-mediated processes, inflammatory processes, and structural abnormalities.

In instances when a diagnosis is needed urgently to guide therapy, such as in acute renal failure, the biopsy can be processed rapidly and the diagnosis communicated within hours of receipt. A histology technician and a renal pathologist are on call 24 hours a day, 7 days a week for STAT biopsy processing and interpretation.

M.E. Fidler, M.D., medical director
J.M. Schafer, supervisor