Mayo Express Care

By Mayo Clinic Staff

Mayo Express Care services are available at north, south and downtown Rochester locations.

North and south locations

Mayo Express Care north and south locations are walk-in clinics offering care on a first-come, first-served basis with sign-up on arrival. Staff treat conditions and other medical issues that require prompt treatment. No appointments are scheduled and services are covered by most medical benefit plans, including Mayo Clinic medical plans. Other cost-sharing amounts such as coinsurance and a deductible may apply.

For Mayo Clinic patients, visit details will be included in the Mayo medical record so that present and future care providers can follow up and coordinate continuing care.

Language interpretation service is offered to non-English-speaking patients. Patients are not charged for the interpreting services.

Express Care North

Northwest Plaza
3454 55th St. NW
Rochester, MN 55901

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Express Care South

Hy-Vee South
500 Crossroads Drive SW
Rochester, MN 55902

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When you arrive at the north or south Mayo Express Care location, please use the sign-in registration sheet. Appointments are available in 15-minute increments.


8 a.m. to 8 p.m. Monday through Friday
9 a.m. to 5 p.m. Saturday and Sunday
Holiday hours vary.

All Express Care sites close on the second Wednesday of every month from 1:30 to 3:00 p.m. They are also closed on Thanksgiving, Christmas and New Year's Day.

The last patient appointment is accepted 15 minutes before closing (7:45 p.m. on weekdays, 4:45 p.m. on weekends and 3:45 p.m. on holidays).

Downtown location (Mayo Clinic employees only)

Mayo Express Care's downtown location provides care to Mayo Clinic staff (not dependents) needing care for minor health issues. Express Care is located on the fourth floor of the Mayo Building off the staff elevators.

Appointments need to be scheduled via Patient Online Services or at the downtown Mayo Express Care lobby kiosk.


8 a.m. to 4 p.m. Monday through Friday
Closed on weekends
Holiday hours match those of primary care sites

St. Marys location (Mayo Clinic employees only)

Mayo Express Care is located on the first floor of the Domitilla Building near the employee shuttle.


5 p.m. to 8 p.m. Monday through Friday
Closed on weekends
Holiday hours match those of primary care sites


Caregivers are integrated members of the Mayo Clinic primary care team. They are board-certified Mayo Clinic nurse practitioners and physician assistants supported by primary care providers.


Services are available to patients 18 months and older (at Mayo Express Care north and south locations) unless otherwise noted.

Conditions treated include:

  • Allergies (age 6+)
  • Bladder infections (females age 12+)
  • Deer tick bites (age 8+)
  • Ear pain
  • Minor skin infections
  • Pink eye
  • Rashes
  • Respiratory illness (ages 18 months to 74 years)
  • Sinus infections (age 6+)
  • Sore throat
  • Vomiting and diarrhea (ages 5 to 74 years)

Services offered include:

  • Ear wash
  • Pregnancy testing
  • Vaccination (flu, pneumonia, Td, Tdap, meningococcal)
  • Wart removal (up to 4 warts per visit; service not available at the St. Marys location)