Cutaneous T-cell Lymphoma

Types

Cutaneous T-cell lymphoma (CTCL) is rare. It is not contagious or inherited. Its cause is unknown, but Mayo researchers continue to study the origin of lymphoma.

In CTCL, certain cells of the lymph system (T-lymphocytes) become cancerous and affect the skin. People with CTCL can have many different symptoms. In the early stages, the skin may itch and develop dry, pink or red patches. Later, skin tumors may develop, and skin may become infected or develop sores.

There are two main types of CTCL:

• Mycosis fungoides (MF). MF begins as pink or red patches that can appear anywhere on the skin. Tumors that look like mushrooms (which are fungi) may develop — hence the name fungoides.
• Sezary syndrome. People with this form of lymphoma are often red from head to toe and experience hot, sore, extremely itchy skin. Other symptoms may include hair loss, thickening of palms and soles, and drooping eyelids. Lymphoma cells are typically found in the blood as well as the skin. Sometimes people with MF develop Sezary syndrome.