Chronic Obstructive Pulmonary Disease

Research

Mayo Clinic doctors have made important scientific contributions to the testing and treatment of COPD.

Robert Hyatt, M.D., former director of the Mayo Pulmonary Function Lab, developed the flow volume curve, an important part of pulmonary testing. Mayo Clinic was one of 10 centers participating in the Lung Health Study, the largest COPD study ever funded by the National Heart, Lung and Blood Institute (NHLBI). Mayo was one of 17 centers participating in the National Emphysema Treatment Trial.

In cooperation with the Veterans Administration Medical Center in Minneapolis, Mayo Clinic in Rochester is one of seven centers in the new COPD Clinical Research Network — funded by NHLBI. Mayo Clinic was recently selected as the radiology center and one of five clinical centers for the NHLBI-funded Lung Tissue Research Consortium, which supports research on the causes of COPD and pulmonary fibrosis.

Mayo Clinic doctors published the first clinical description of alpha-1 antitrypsin deficiency in 1969. Mayo Clinic participated in the original Registry for Alpha-1 Antitrypsin Deficiency (1988-1996), funded by the National Institutes of Health. Currently, Mayo Clinic is nationally recognized as a Clinical Resource Center by the Alpha One Foundation , a nonprofit organization that supports clinical research and health resources information for patients and families with this disorder.

The Thoracic Diseases Research Unit in Rochester is a group of pulmonary scientists investigating basic mechanisms of interstitial, infectious, and obstructive lung disorders. The Pulmonary Clinical Research Center at Mayo Clinic in Rochester is one of the largest contract clinical research centers in pulmonary medicine in the country. The center participates in many trials of new medications in late-stage development for treatment of COPD.

Mayo Research Related to Chronic Obstructive Pulmonary Disease

Gay PC. Chronic obstructive pulmonary disease and sleep. Respir Care. 2004 Jan;49(1):39-51; discussion 51-2. Review. [Abstract]

Cowl CT. Chapter: Chronic obstructive pulmonary disease. Lang RS, Hensrud DD, editor(s). Clinical preventive medicine 2nd edition. Chicago: American Medical Association; 2004. p. 689-95. [No Abstract Available]

Pietila MP, Thomas CF. Inflammation and infection in exacerbations of chronic obstructive pulmonary disease. Semin Respir Infect. 2003 Mar;18(1):9-16. Review. [Abstract]

Levine S, Nguyen T, Kaiser LR, Rubinstein NA, Maislin G, Gregory C, Rome LC, Dudley GA, Sieck GC, Shrager JB. Human diaphragm remodeling associated with chronic obstructive pulmonary disease: clinical implications. Am J Respir Crit Care Med. 2003 Sep 15;168(6):706-13. Epub 2003 Jul 11. [Abstract]

Palm KH, Decker WW. Acute exacerbations of chronic obstructive pulmonary disease. Emerg Med Clin North Am. 2003 May;21(2):331-52, viii. Review. [Abstract]

Warner DO. Chapter: Chronic obstructive pulmonary disease and restrictive lung disease. Faust RJ, editor(s). Anesthesiology review 3rd edition. New York: Churchill Livingstone; 2002. p. 87-8. [No Abstract Available]

Afessa B, Morales IJ, Scanlon PD, Peters SG. Prognostic factors, clinical course, and hospital outcome of patients with chronic obstructive pulmonary disease admitted to an intensive care unit for acute respiratory failure. Crit Care Med. 2002 Jul;30(7):1610-5. [Abstract]

Altose MD, Redline S, Deitz CD, Quinlan KJ, Eichenhorn MS, Conway WA, Jentons RL, Braden K, Ketchum M, Wise RA, Permutt S, Rand CS, Daniel M, Santopietro V, Weeks KA, Scanlon PD, Patel AM, Utz JP, Williams DE, Caron GM, Micras KS, Buist AS, Johnson LR, Bortz VJ, Persons SL, Connett JE, et. al. Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. New England Journal of Medicine 2000 Dec 28;343(26):1902-09. [No Abstract Available]

Scanlon PD, Connett JE, Waller LA, Altose MD, Bailey WC, Buist AS. Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):381-90. [Abstract]

Johnston DL, Scanlon PD, Hodge DO, Glynn RB, Hung JC, Gibbons RJ. Pulmonary function monitoring during adenosine myocardial perfusion scintigraphy in patients with chronic obstructive pulmonary disease. Mayo Clin Proc. 1999 Apr;74(4):339-46. [Abstract]

Kanner RE, Connett JE, Williams DE, Buist AS. Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study. Am J Med. 1999 Apr;106(4):410-6. [Abstract]

Martinez M, Lee AS, Hellinger WC, Kaplan J. Vertebral Aspergillus osteomyelitis and acute diskitis in patients with chronic obstructive pulmonary disease. Mayo Clin Proc. 1999 Jun;74(6):579-83. Review. [Abstract]

Boonyaratavej S, Oh JK, Tajik AJ, Appleton CP, Seward JB. Comparison of mitral inflow and superior vena cava Doppler velocities in chronic obstructive pulmonary disease and constrictive pericarditis. J Am Coll Cardiol. 1998 Dec;32(7):2043-8. [Abstract]

Johnston DL, Hodge DO, Glynn RB, Gibbons RJ. Adenosine scintigraphy in patients with chronic obstructive pulmonary disease: routine pretreatment with a bronchodilator. (Abstract 8.11). Journal of Nuclear Cardiology 1997 Jan-Feb;4(1 Part 2 Suppl):S7. [No Abstract Available]

Warner DO, Warner MA, Offord K, Schroeder D, Maxson P, Scanlon P. Chronic obstructive pulmonary disease and perioperative pulmonary complications. (Abstract a1119). Anesthesiology 1997 Sep;87((3 Suppl)). [No Abstract Available]