Colon Cancer

Clinical Trials

Below is a list of Colon Cancer clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Multinational National Institutes of Health-Sponsored Colon Cancer Family Registry
This study is being done to identify individuals from families that have experienced one or more instances of colon cancer, in order to study these families in detail. The current understanding of the environmental and genetic factors that contribute to the development of colon cancer are poorly understood.
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Aspirin and Eflornithine in Treating Patients at High Risk for Colorectal Cancer
Primary Objectives: I. The proportion of subjects with an adenoma recurrence at the 1-year follow-up colonoscopy exam. II. To compare this adenoma recurrence rate for eflornithine (DFMO) + aspirin to the double placebo to see if there is improvement in the adenoma recurrence rate in this patient population.
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Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer
OBJECTIVES: Primary objectives - To determine the preliminary efficacy of the combination of azacitidine and entinostat in patients with metastatic colorectal cancer. Secondary objectives - To explore the effects of this regimen on the time to progression in these patients.
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Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy
OBJECTIVES: Primary - To determine whether 2 schedules of calcium gluconate and magnesium sulfate infusions (given before and after chemotherapy or just before chemotherapy) can prevent or ameliorate chronic, cumulative oxaliplatin-induced sensory neurotoxicity in patients with colon or rectal cancer receiving adjuvant FOLFOX chemotherapy comprising leucovorin calcium, fluorouracil, and oxaliplatin.
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Colorectal Polyp Discrimination Using High-Definition Narrow Band Imaging
Information will be collected. Images will be taken.
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Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
OBJECTIVES: Primary - To compare the progression-free survival (PFS) of elderly patients with metastatic colorectal carcinoma who are randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with or without oxaliplatin. Secondary - In a prospectively planned pooled analysis with a similar trial to be conducted by the Japanese Clinical Oncology Group (JCOG), evaluate and compare the overall survival (OS) of elderly patients with metastatic colorectal carcinoma who
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E5202 "Phase III Study Comparing 5-FU (5-fluorouracil) Leucovorin and Oxaliplatin versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab (Avastin) in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers"
At the present time, researchers do not know if chemotherapy, for stage II colon cancer, can help reduce the chances that a patient's cancer might come back. Currently, the standard of care for individuals with this type of cancer is to receive no chemotherapy.
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Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer
Patients who are at average risk of developing colorectal cancer who are eligible for colorectal cancer screening will be asked to collect a single stool sample for the Exact CRC screening test and for the commercially available FIT assay.
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Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
OBJECTIVES: Primary - To compare disease-free survival of patients with resected stage III colon cancer treated with adjuvant FOLFOX chemotherapy comprising oxaliplatin, fluorouracil, and leucovorin calcium with versus without celecoxib. Secondary - To contribute to an international prospective pooled analysis comparing disease-free survival of patients treated with these regimens.
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Selenium for Prevention of Adenomatous Colorectal Polyps
OBJECTIVES: Primary - Compare the effects of selenium vs placebo on the recurrence of adenomatous colorectal polyps, in terms of histologic type, degree of dysplasia, number, size, and location, in patients with adenomatous colorectal polyps.
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