Cervical Cancer

Clinical Trials

Below is a list of Cervical Cancer clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Phase 2 Study of Intensity Modulated Radiation Therapy (IMRT) to the Pelvis +/- Chemotherapy for Post-operative Patients with either Endometrial or Cervical Cancer
Patients are being asked to take part in this research study because they have endometrial or cervical cancer that has a high risk for coming back as pelvic or endometrial cancer. The purpose of this study is to determine if an advanced radiation therapy delivery technique called intensity modulated radiation therapy (IMRT see definition below) can spare the patient's normal tissue, including small bowel and large bowel, from radiation.

Definition of IMRT: Many normal tissues, including small bowel and large bowel, are very close to areas at high risk of cancer coming back, such as lymph nodes and vagina. Standard radiation techniques cannot avoid delivering radiation to these normal tissues that do not need to get radiation. IMRT tries to lower the amount of radiation that normal tissues receive, while still delivering the desired amount of radiation to the cancer and to areas that the study doctor thinks may have cancer cells, such as lymph nodes in the pelvis. IMRT does this by using multiple, complicated computer-controlled radiation beams aimed at a patient's cancer.
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GOG-0219, A Phase III, Randomized Study of Weekly Cisplatin and Radiation versus Cisplatin and Tirapazamine (IND #46525) and Radiation in Stage IB2, IIA, IIB, IIIB and IVA Cervical Cancer Limited to the Pelvis
Patients are being asked to take part in this research study because they have cancer of the cervix. This study is being done to determine if combining Tirapazamine (TPZ) with Cisplatin during radiation therapy increases the amount of time until a patient's cancer returns compared with Cisplatin and radiation therapy alone.

The Tirapazamine (TPZ) used in this study is considered investigational, which means it has not been approved by the U.S. Food and Drug Administration (FDA) for either routine clinical use or for the use described in this study. However, the FDA has allowed the use of this drug in this research study.
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