The first line of treatment for Clostridium difficile is aggressive use of specific antibiotics that kill the C. difficile bacterium:
If you are dehydrated you may be hospitalized for close monitoring, and to receive antibiotics and rehydration.
In rare cases, surgery may be needed if you have severe C. difficile infection, complications such as hemorrhage or bowel perforation, or if your condition does not improve with medication.
In as many as 30 percent of people, the C. difficile infection returns after their antibiotic treatment (relapse). The risk of relapse is higher if you have:
Treating a recurrence of C. difficile involves taking antibiotics or restoring the healthy bacteria in your intestines with nonpathogenic yeast such as Saccharomyces boulardii.