The eight-story Davis Building remains the clinic's largest facility. The Bundy Cafe & Atrium and Mayo Pharmacy are located on the main floor. Other patient facilities include the Mayo Building and the Cannaday Building, which houses the gift shop.
All three buildings are connected by an enclosed walkway and linked to The Inn at Mayo Clinic, a 78-suite hotel. The Courtyard by Marriott, a 146-room hotel, is located near the entrance of the campus.
The Birdsall Medical Research Building has 10 laboratories where scientists investigate neurological diseases such as Alzheimer's. The Griffin Cancer Research Building was completed in 2002 and is the first building on the Jacksonville campus devoted primarily to cancer research.
Mayo Clinic hospital, which opened in April 2008, integrates inpatient and outpatient services on the Mayo campus in Jacksonville. It has 214 beds and 22 operating rooms and offers care in 20 medical and 15 surgical specialties. It also includes a full-service Emergency Department.