Barrett's Esophagus

Clinical Trials

Below is a list of Barrett's Esophagus clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Biomarkers in Phototherapy of Barrett's Esophagus
This study is being done to find out if photodynamic therapy (treatment with a red light and a drug called photofrin) works as well for patients who have biomarkers (a presence of abnormalities in molecules of cells that may or may not help predict cancer) present in their Barrett's esophagus as compared to patients who do not have biomarkers present. Participants should have a history of Barrett's esophagus.
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Endoscopic Therapy of Early Esophageal Cancer in Patients with Barrett's Esophagus
This research study is being done to see if treatment for esophageal cancer can be done using endoscopy. The standard method of treating this type of cancer is surgical removal of the esophagus. The study will determine if removing just the cancer with endoscopy is enough treatment or if the addition of another treatment called photodynamic therapy (treatment with a red light and a drug called sodium porfimer) is needed.
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Familial Barrett's Esophagus Study
A group of doctors and scientists at the Mayo Clinic in Rochester, Minnesota, along with doctors from many other medical centers throughout the US, are working together to advance our understanding of Barrett's esophagus and esophagus cancer. The main aim of the present study is to collect blood for future testing. Once all the samples have been collected, tests to identify genes that may be involved in the development of Barrett's will be performed. A future goal is to learn if there is a genetic difference between those people who have Barrett's and develop cancer, and those who do not.
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Gene Analysis for the Understanding of Barrett's Esophagus and Esophagus Cancer
This study is being done to advance the understanding of how esophagus cancer and Barrett's Esophagus develop as well as ways to treat these conditions. This will be done by analyzing blood and tissue to identify genes that may be involved in the development of esophagus cancer and Barrett's Esophagus.
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Phase II Study Comparing Esomeprazole (Nexium)Versus Esomeprazole (Nexium) + Two Doses of Aspirin in Barrett's Esophagus Patients
This study is being done for these reasons:
- To learn about any effects (good and bad) esomeprazole (an acid blocker) with or without aspirin has on a patient and their esophagus;
- To find out if esomeprazole and aspirin have an effect on a patient's risk for getting cancer of the esophagus;
- There are no U.S. Food and Drug (FDA) approved drugs for the prevention of esophageal cancer.
Esomeprazole is a drug which has been approved by the FDA for the treatment of gastroesophageal reflux disease (GERD) and duodenal (small intestine) ulcers. Aspirin is a drug which is used for the treatment of joint inflammation
conditions, pain, fever, strokes, and heart disease. At the present time, neither of these agents is approved for the prevention of esophageal cancer.
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