Anatomic Pathology in Minnesota

In Situ Hybridization Laboratory

In situ hybridization (ISH) analysis of nucleic acids in tissue sections was first reported over 30 years ago with many advances and refinements over the ensuing years. The application of ISH to the study of DNA alterations in solid tissue has only recently gained popularity.

The In Situ Hybridization Laboratory was developed within the division of Anatomic Pathology in 1993. Currently the laboratory offers approximately 20 clinical tests, and the test volume has grown to over 350 clinical tests per month. Approximately 25 percent of the testing is performed for Mayo Clinic patients and 75 percent for clients outside of Mayo Clinic requesting testing or consultation through Mayo Medical Laboratories.

Most of the testing done in the laboratory is in the detection of infectious agents, particularly viruses, and include tests to detect Human Papilloma Virus, Epstein-Barr virus, Polyoma (BK) virus and Herpes Simplex Virus.

R. V. Lloyd, M.D., Ph.D., Medical Director, In situ Hybridization Laboratory
E.D. Remstein, Associate Medical Director, In Situ Hybridization Laboratory
T.B. Plummer, HT, HTL (ASCP), Supervisor, In situ Hybridization Laboratory