Amyloidosis

Treatment

The goal of treatment is to limit further production of the amyloid protein. Treatment depends on which type of amyloid protein is present, where it is being deposited and how it is affecting organ(s) and other tissues. Though there is no cure for amyloidosis, treatment targeting the cells which make the amyloid protein may limit its further production and improve overall function.

An important aspect of managing amyloidosis is aggressively treating the symptoms caused by the disease. This is primarily done with medications and diet. For example, if amyloidosis affects the heart or kidneys, a low-salt diet may help to limit fluid retention. Diuretics or other medications may also help. Well-balanced nutrition is important to provide the body with adequate energy. Although amyloid is a protein, there is no link between dietary intake of protein and amyloidosis.

Researchers are studying other therapies to determine their place in the treatment of amyloidosis. These include:

Peripheral Stem Cell Transplantation

Peripheral stem cell transplantation involves using high-dose chemotherapy and transfusion of previously collected immature blood seed cells (stem cells) to replace diseased or damaged marrow. These cells may be the patient's own (autologous transplant) or from a donor (allogeneic transplant). See bone marrow transplants at Mayo Clinic.

Other Therapies

Therapies include melphalan (Alkeran), an agent also used to treat some cancers, and prednisone, a corticosteroid used for its anti-inflammatory effects. Mayo is continuously testing new medications and therapies to determine which may be effective in managing amyloid deposits and provide options for most amyloidosis.